The CPU is a very register-oriented design, so there are quite a few registers accessible. (There are some internal work registers as well, but these are invisible to the architecture side of things.) There are eight 16-bit general-purpose registers, the first four of which can be accessed as separate eight-bit registers; these comprise the General Register Block. There are also three 8-bit segment-selector registers (more on them in the Addressing page) and one 8-bit status register, which comprise the Special Register Block. Finally, there is one 16-bit stack pointer and one 16-bit program counter; these are not grouped into a register block.
| General Register Block |
| AL, AH, BL, BH, CL, CH, DL, DH | 8-bit general-purpose registers |
| AX, BX, CX, DX | Concatenated 16-bit general-purpose registers |
| EX, FX, GX, HX | 16-bit general-purpose registers |
| Special Register Block |
| CS, DS, SS | 8-bit segment selectors |
| SF | 8-bit status register |
| Other registers |
| SP | 16-bit stack pointer |
| PC | 16-bit program counter |
Only the registers in the General Register Block can be accessed by most instructions; however, there are instructions to transfer to and from the registers in the Special Register Block and the stack pointer. The program counter cannot be accessed as a register by any instruction. The registers in the General Register Block are indicated in the instruction post-byte by a corresponding number:
| AL | AH | BL | BH | CL | CH | DL | DH |
| 0 | 1 | 2 | 3 | 4 | 5 | 6 | 7 |
| AX | BX | CX | DX | EX | FX | GX | HX |
| 8 | 9 | A | B | C | D | E | F |
Similarily, the registers in the Special Register Block have corresponding numbers for the instructions that access them:
The SF status register contains various status flags indicating the results of the different operations. It also contains the Interrupt Mask bit, which disables interrupts 0 through 5 when set.
| N | Negative result | Z | Zero result | C | Arithmetic carry | O | Arithmetic overflow |
| I | Interrupt mask | A | Address exception | U | Opcode exception | E | Even result |